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研究業績

2018年(平成30年)

  • PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes.
    Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, Kaburagi Y, Asahara SI, Kido Y, Minami S, Kasuga M, Matsumoto M.
    Scientific Reports.. 2018 Sep 24;8(1):14290.
    doi: 10.1038/s41598-018-32575-z.
  • Urinary afamin levels are associated with the progression of diabetic nephropathy
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    Kaburagi Y, Takahashi E, Kajio H, Yamashita S, Yamamoto-Honda R, Shiga T, Okumura A, Goto A, Fukazawa Y, Seki N, Tobe K, Matsumoto M, Noda M, UnokiKubota H
    Diabetes Research and Clinical Practice. 2018 Mar 6. pii: S0168-8227(17)31788-6. [Epub ahead of print]
    doi: 10.1016/j.diabres.2018.02.034.
  • Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
    Watanabe H, Inaba Y, Kimura K, Matsumoto M, Kaneko S, Kasuga M, Inoue H
    Nature Communicationsvolume. 2018 Jan 2;9(1):30.
    doi: 10.1038/s41467-017-02537-6.

2017年(平成29年)

  • Circadian clock regulates hepatic polyploidy by modulating Mkp1Erk1/2 signaling pathway
    Chao HW, Doi M, Fustin JM, Chen H, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N, Yamaguchi Y, Yasunaga JI, Matsuoka M, Sakai M, Matsumoto M, Hamada S, Okamura H
    Nature Communications. 2017 Dec 21;8(1):2238.
    doi: 10.1038/s41467-017-02207-7.
  • Alleviation of lipopolysaccharide/dgalactosamineinduced liver injury in leukocyte cellderived chemotaxin 2 deficient mice
    Okumura A, Saito T, Tobiume M, Hashimoto Y, Sato Y, Umeyama T, Nagi M, Tanabe K, UnokiKubota H, Kaburagi Y, Hasegawa H, Miyazaki Y, Yamagoe S
    Biochemistry and Biophysics Reports. 2017 Oct 13;12:166-171. eCollection 2017 Dec.
    doi: 10.1016/j.bbrep.2017.09.011.
  • Proteomic analysis of serum biomarkers for prediabetes using the Long-Evans Agouti rat, a spontaneous animal model of type 2 diabetes mellitus
    Takahashi E, Unoki-Kubota H, Shimizu Y, Okamura T, Iwata W, Kajio H, Yamamoto-Honda R, Shiga T, Yamashita S, Tobe K, Okumura A, Matsumoto M, Yasuda K, Noda M, Kaburagi Y
    Journal of Diabetes Investigation. 2017 Sep;8(5):661-671. Epub 2017 Mar 27.
    doi: 10.1111/jdi.12638.
  • Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease
    Watanabe H, Inaba Y, Kimura K, Asahara SI, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H
    The Journal of Nutrition. 2017 Jan;147(1):52-60. Epub 2016 Nov 30
    doi: 10.3945/jn.116.231662.

2016年(平成28年)

  • The GCN5-CITED2-PKA module controls glucose metabolism through a cAMP-induced substrate switch
    Sakai M, Tsujimura-Hayakawa T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M
    Nature Communications. 2016 Nov 22;7:13147.
    doi: 10.1038/ncomms13147.
  • HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance
    Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Aminuddin A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K
    Diabetes. 2016 Dec;65(12):3649-3659. Epub 2016 Sep 13.
    doi:
  • p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress.
    Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, Takubo K.
    Cell Stem Cell. 2016 Aug 4;19(2):192-204. Epub 2016 Jun 23.
    doi: 10.1016/j.stem.2016.05.013.
  • Central Insulin Action Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine Receptor
    Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H
    Cell Reports. 2016 Mar 15;14(10):2362-74. Epub 2016 Mar 3.
    doi: 10.1016/j.celrep.2016.02.032.
  • Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice
    Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima Y
    The FASEB Journal. 2016 Feb;30(2):849-62. Epub 2015 Oct 29.
    doi: 10.1096/fj.15-274449.

2015年(平成27年)

  • Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c
    Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matsumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y
    Proceedings of the National Academy of Sciences of the United States of America. 2015 Jul 7;112(27):8332-7. Epub 2015 Jun 22.
    doi: 10.1073/pnas.1422104112.