研究業績

2023年（令和5年）

Matsukawa T, Yagi T, Uchida T, Sakai M, Mitsushima M, Naganuma T, Yano H, Inaba Y, Inoue H, Yanagida K, Uematsu M, Nakao K, Nakao H, Aiba A, Nagashima Y, Kubota T, Kubota N, Izumida Y, Yahagi N, Unoki-Kubota H, Kaburagi Y, Asahara SI, Kido Y, Shindou H, Itoh M, Ogawa Y, Minami S, Terauchi Y, Tobe K, Ueki K, Kasuga M, Matsumoto M.
Hepatic FASN deficiency differentially affects nonalcoholic fatty liver disease and diabetes in mouse obesity models.
JCI Insight. 2023 Sep 8;8(17):e161282. doi: 10.1172/jci.insight.161282.
Hirano D, Unoki-Kubota H, Imasawa T, Yamamoto-Honda R, Kajio H, Yamashita S, Fukazawa Y, Seki N, Noda M, Kaburagi Y.
Independent risk factors of rapid glomerular filtration rate decline in patients with type 2 diabetes with preserved kidney function and normoalbuminuria: A multicenter cohort study.
J Diabetes Investig. 2023 Jul;14(7):874–882. doi: 10.1111/jdi.14011.

Unoki-Kubota H, Hirano D, Imasawa T, Yamamoto-Honda R, Kajio H, Yamashita S, Fukazawa Y, Seki N, Noda M, Kaburagi Y.
Independent risk factors of rapid renal function decline in patients with type 2 diabetes with preserved kidney function.
International Diabetes Federation Western Pacific Congress 2023 / 15th Asian Association for the Study of Diabetes Scientific Meeting, Kyoto, Japan, July 21–23, 2023.
Imasawa T, Unoki-Kubota H, Hirano D, Kitamura H, Kaburagi Y.
Exploration of prognostic factors in diabetic nephropathy with nodular lesion using transcriptome analysis of human kidney tissues.
60th European Renal Association Congress, Milan, Italy, June 15–18, 2023.
M. Ishikane M. Unoki-Kubota H, Moriya A, Ando H, Kaburagi Y, Iwamoto N, Kimura M, Ohmagari N.
Evaluation of artus SARS-CoV-2 Prep&Amp UM Kit for SARS-CoV-2 Detection, a rapid direct PCR method for the diagnosis of COVID-19.
33rd European Congress of Clinical Microbiology & Infectious Diseases, Copenhagen, Denmark, April 15–18, 2023.

久保田浩之, 伊藤恵実, 平野大志, 今澤俊之, 梶尾裕, 山下滋雄, 深澤由香, 関直人, 鏑木康志．
糸球体上皮細胞におけるPDK1-FOXO 経路による機能調節．
第66回日本糖尿病学会年次学術集会、鹿児島、2023年5月11日～5月13日．

Hirano D, Unoki-Kubota H, Imasawa T, Yamamoto-Honda R, Kajio H, Yamashita S, Fukazawa Y, Seki N, Noda M, Kaburagi Y.
Independent risk factors of rapid glomerular filtration rate decline in patients with type 2 diabetes with preserved kidney function and normoalbuminuria: A multicenter cohort study.
J Diabetes Investig. 2023 Jul;14(7):874-882. doi: 10.1111/jdi.14011.

Imasawa T, Unoki-Kubota H, Hirano D, Kaburagi Y.
Transcriptome analysis of human kidney tissues to explore prognostic factors in diabetic kidney disease with nodular lesion.
American Society of Nephrology (ASN) Kidney Week 2022, Orland, FL, USA, November 3-6, 2022.

今澤俊之, 久保田浩之, 平野大志, 北村博司, 鏑木康志．
ラット初代培養ポドサイトを用いた低出生体重関連巣状分節性糸球体硬化症の発症機序解明．
第65回日本腎臓学会学術総会、神戸、2022年6月10日～6月12日．
久保田浩之, 伊藤恵実, 平野大志, 今澤俊之, 梶尾裕, 山下滋雄, 深澤由香, 関直人, 鏑木康志．
2型糖尿病患者における推算糸球体濾過量（eGFR）漸減関連因子の探索．
第65回日本糖尿病学会年次学術集会、神戸、2022年5月12日～5月14日．

Urinary afamin levels are associated with the progression of diabetic nephropathy

Kaburagi Y, Takahashi E, Kajio H, Yamashita S, Yamamoto-Honda R, Shiga T, Okumura A, Goto A, Fukazawa Y, Seki N, Tobe K, Matsumoto M, Noda M, UnokiKubota H
Diabetes Research and Clinical Practice. 2018 Mar 6. pii: S0168-8227(17)31788-6. [Epub ahead of print]
doi: 10.1016/j.diabres.2018.02.034.

Alleviation of lipopolysaccharide/dgalactosamineinduced liver injury in leukocyte cellderived chemotaxin 2 deficient mice
Okumura A, Saito T, Tobiume M, Hashimoto Y, Sato Y, Umeyama T, Nagi M, Tanabe K, UnokiKubota H, Kaburagi Y, Hasegawa H, Miyazaki Y, Yamagoe S
Biochemistry and Biophysics Reports. 2017 Oct 13;12:166-171. eCollection 2017 Dec.
doi: 10.1016/j.bbrep.2017.09.011.
Proteomic analysis of serum biomarkers for prediabetes using the Long-Evans Agouti rat, a spontaneous animal model of type 2 diabetes mellitus
Takahashi E, Unoki-Kubota H, Shimizu Y, Okamura T, Iwata W, Kajio H, Yamamoto-Honda R, Shiga T, Yamashita S, Tobe K, Okumura A, Matsumoto M, Yasuda K, Noda M, Kaburagi Y
Journal of Diabetes Investigation. 2017 Sep;8(5):661-671. Epub 2017 Mar 27.
doi: 10.1111/jdi.12638.
Biosci Trends. A novel angiogenic peptide, ΔADT: A truncated adrenotensin peptide revealed by secretory peptidome analysis of human
Okumura A, Takahashi E, Unoki-Kubota H, Kaburagi Y
BioScience Trends. 2017 Jan 16;10(6):500-506. Epub 2016 Nov 13.
doi: 10.5582/bst.2016.01189.

Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy
Okumura A, Unoki-Kubota H, Yoshida-Hata N, Yamamoto-Honda R, Yamashita S, Iwata M, Tobe K, Kajio H, Noda M, Katai N, Yamagoe S, Kaburagi Y
Clinica Chimica Acta. 2016 Dec 1;463:145-149. Epub 2016 Oct 29.
doi: 10.1016/j.cca.2016.10.031.
Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold
Zheng H, Miyakawa T, Sawano Y, Asano A, Okumura A, Yamagoe S, Tanokura M
Journal of Biological Chemistry. 2016 Aug 12;291(33):17133-42. Epub 2016 Jun 22.
doi: 10.1074/jbc.M116.720375.